More papers with our contributions!

The publication spree continues! Today, two papers were published, to which the Vastenhouwies had contributed.

The first paper, with the contribution of Shivali, describes a micropeptide, that can be used to probe the functions of endogenous condensates. The Hnisz lab developed a micropeptide sequence termed "killswitch". This can be recruited to endogenous condensate-forming proteins which leads to freezing of these condensates. The killswitch is a very useful tool in targeting and probing the function of specific condensates in vivo. To test the killswitch function for an endogenous condensate, Shivali fused the killswitch peptide to the transcription factor Nanog to freeze Nanog clusters.  She found that this led to a decreased transcriptional output and a smaller transcription body at our favourite locus mir430! You can read the paper by clicking this link.

The second paper, to which Eleonora contributed, describes a novel super-resolution imaging method to image thick samples. s2ISM (super-resolution sectioning ISM) is a powerful method  in image scanning microscopy that overcomes the limitations in resolution, signal quality, and optical sectioning. By leveraging fast detector arrays and image reconstruction algorithm, this method delivers high-resolution, high signal-to-noise images from a single scan—while still improving 3D sectioning in thick samples. s2ISM opens the door to more accurate and versatile imaging in biological research. You can read the paper by clicking here.

Enjoy the reads!